Homo sapiens Raw sequence reads. Homo sapiens

As an important immune cell in the body, macrophages are involved in the pathogenesis of chronic inflammatory diseases. THP-1 cells are a monocyte cell line derived from human leukemia and have the potential for further differentiation. They are used to study human primary monocytes/macrophages. The most common in vitro model cell for cell function applications. As a natural immune stimulant, lipopolysaccharide can stimulate THP-1 macrophages to synthesize and release a variety of cytokines. Using PMA to induce differentiation combined with LPS stimulation to establish THP-1 inflammatory cell models is often used for inflammatory mechanism research and anti-inflammatory agents Discovery and screening. MiR-4286 has also been reported in cancer and inflammation, but its mechanism is not clear. Therefore, genome sequencing is very necessary to explore its related mechanisms.