tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-2-(methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5,6-tetramethoxytetrahydro-2H-pyran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-2-(methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5,6-tetramethoxytetrahydro-2H-pyran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one Descriptor: 6-azanyl-2-(methylamino)-4-[2-[(2~{R},3~{R},4~{S},5~{R},6~{S})-3,4,5,6-tetramethoxyoxan-2-yl]ethyl]-1,7-dihydroimidazo[4,5-g]quinazolin-8-one, GLYCEROL, Queuine tRNA-ribosyltransferase, ... Authors: Ehrmann, F.R, Heine, A, Klebe, G. Deposit date: 2016-08-14 Release date: 2017-08-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Carbohydrate-based Inhibitors targeting the Ribose-34 pocket of Z.mobilis TGT and changing the oligomeric state of the homodimer To be published

tRNA鸟嘌呤转糖基酶（tRNA guanine Transglycosylase，TGT）与6-氨基-2-(甲氨基)-4-(2-((2R,3R,4S,5R,6S)-3,4,5,6-四甲氧基四氢-2H-吡喃-2-基)乙基)-1H-咪唑并[4,5-g]喹唑啉-8(7H)-酮共结晶复合物（空间群P2₁）。描述符：6-氨基-2-(甲氨基)-4-[2-[(2R,3R,4S,5R,6S)-3,4,5,6-四甲氧基吡喃-2-基]乙基]-1,7-二氢咪唑并[4,5-g]喹唑啉-8-酮、甘油、奎因tRNA-核糖基转移酶（Queuine tRNA-ribosyltransferase）。作者：Ehrmann, F.R.、Heine, A.、Klebe, G.。存储日期：2016年8月14日；发布日期：2017年8月30日；最后修改日期：2024年1月10日。实验方法：X射线衍射（分辨率2.36埃）。引用文献：《靶向运动发酵单胞菌（Z. mobilis）TGT的核糖34口袋并改变同二聚体寡聚状态的糖类抑制剂》（待发表）