Primary mucosal melanoma (MM), which arise from melanocytes located in mucosal membranes, frequently present late and have a poor prognosis; ~14% 5-year survival rate. MM makes up only ~1.4% of all me
1Cervical, 2endometrial, 3ovarian, and 4vulvar carcinomas. 51 cervical and 5 endometrial samples had 2 PIK3CA mutations, and 11 endometrial samples had 2 PTEN mutations in the same tumour. One endomet
The mutational processes dictating the accumulation of mutations in genomes are shaped by genetic background, environment and their interactions. Accurate quantification of mutation rates and spectra
This study was the first-known large-scale effort to uncover the mutational spectrum of head and neck cancers. We analyzed whole-exome sequence from 92 tumor-normal pairs and retained 74 of them for s
This study demonstrated that the integration of gene manipulation in metabolic engneered strain Clostridium tyrobutyricum PAK-Em and further evolutionary engineered Clostridium tyrobutyricumHyd-Em.
