Protease Inhibitor (PI)-Resistance Mutation Patterns in Viruses From Patients Receiving Lopinavir/r and their Predicted Effect on PI Cross Resistance*.

Footnote: *36 patterns of PI-resistance mutations from 55 patients.†PI-resistance mutations included L10F, L24I, L33F, V32I, M46I/L, I50V, I54V, L76V, V82A, I84V, L89V, and L90M. (D30N, I47V, G48V, I50L, I54L/M/T/A/S, and V82T/S/F did not occur in this dataset). V82M and V82C occurred in 2 patients and were represented by V82A. The accessory mutations L10I/V and A71V/T occurred commonly but are not shown. The mutations V11I, F53L, G73S, T74P, N83D, and N88S each occurred in 1 to 3 patients and are also not shown.§Predicted reduced susceptibility to lopinavir/r (LPV), atazanavir/r (ATV), and darunavir/r (DRV) according to the HIVDB drug-resistance interpretation system. Scores ≥60 indicate high-level resistance; scores between 30 and 59, intermediate resistance; scores between 15 and 29, low-level resistance.¶One of more samples with this pattern of study-defined LPVr mutations had additional PI-resistance mutations that influenced the extent of ATVr cross resistance. For example, the sample with I47A also had the mutation N88S which is associated with high-level ATVr resistance.