Effect of cytokine exposure on human islet total cellular insulin content and insulin secretory capacity.

Results are reported as % recovery of total cellular insulin content relative to untreated controls (islets alone). Islet function is assessed by a static glucose stimulated insulin release assay. The stimulation index (SI) is calculated as a ratio of insulin release at high glucose versus low glucose. Insulin release (% insulin content) is reported as insulin secreted at 2.8 mM glucose or 20.0 mM glucose divided by cellular insulin content for corresponding islets. Values are expressed as mean ± SEM.*p†p6 bMSC + cytokine.‡p6 bMSC + cytokine.§p6 pMSC + cytokine.||p6 pMSC + cytokine. (bMSCs) represents bone marrow derived mesenchymal stem cells, (pMSCs) represents pancreatic derived mesenchymal stem cells and (fibro) represents dermal fibroblasts.