A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75. Huo et al

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A delicate balance between antibody evasion and ACE2 affinity for Omicron BA.2.75

Jiandong Huo1,2,3,#,*, Aiste Dijokaite-Guraliuc4,#, Chang Liu4,5,#, Raksha Das4, Piyada Supasa4, Muneeswaran Selvaraj4, Rungtiwa Nutalai4, Daming Zhou2,5, Alexander J. Mentzer4,7, Donal Skelly7,8,9, Thomas G. Ritter7, Ali Amini7,8,10, Sagida Bibi11, Sandra Adele7, Sile Ann Johnson7, Neil G. Paterson6, Mark A. Williams6, David R. Hall6, Megan Plowright12,13, Thomas A.H. Newman12,13, Hailey Hornsby12, Thushan I de Silva12,13, Nigel Temperton14, Paul Klenerman7,8,10,15, Eleanor Barnes7,8,10,15, Susanna J. Dunachie7,8,16,17, Andrew J Pollard11,15, Teresa Lambe5,11, Philip Goulder8,18, OPTIC consortium&, ISARIC4C consortium$, Elizabeth E. Fry2*, Juthathip Mongkolsapaya4,5,*, Jingshan Ren2,*, David I. Stuart2,5,6,*,^, Gavin R Screaton4,5,*

1. State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China
2. Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK
3. Guangzhou Laboratory, Bio-island, Guangzhou 510320, China
4. Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK
5. Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK
6. Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK