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Genome-wide occupancy of LSD1 in HEL human erythroleukemia cell line.

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145401
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We examined the genome-wide distribution of LSD1 bound regions in HEL cells bya ChIP-seq analysis. We found that GATA family transcription factors co-operate with LSD1 to regulate metabolic genes. We also found that LSD1 binds to and represses CEBPA gene enhancer, resulting in the suppression of myeloid cell properties. Examination of LSD1 / DNA interaction in HEL. Two biological replicates were analyzed.
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2021-05-04
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