Three-Component Direct Phosphorylation of Aldehydes and Alkylation of Ketones: Synthesis of γ‑Ketophosphine Oxides under Acidic Conditions
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An effective and economical acid-promoted three-component reaction for the construction of C–P and C–C bonds for the synthesis of γ-ketophosphine oxides with water as the only byproduct was developed. Detailed mechanistic experiments confirmed that the reaction proceeds by phospha-aldol elimination, in which a benzylic carbocation is generated from the phosphorylation of aldehydes, which then reacts with ketone enolates under acidic conditions.
