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Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma

NIAID Data Ecosystem2026-05-02 收录

融合阳性横纹肌肉瘤

转录因子染色质调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279337 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2025-02-12

神经母细胞规范

转录因子染色质调控

Proneural transcription factors mediate stem cell homeostasis in different systems and exhibit impressive oncogenic and reprogramming capacities. In early Drosophila embryos, proneurals regulate neuro

NIAID Data Ecosystem50

TBX3 advances the developmental chromatin landscape towards the hepatic fate [ChIP-seq]

肝细胞分化表观遗传学

转录因子染色质调控

Hepatocytes differentiate from definitive endoderm in response to external signaling cues, however it is unclear how the hepatic lineage is specified and how transcription factors shape the chromatin

NIAID Data Ecosystem20

Protein-intrinsic properties and context-dependent effects regulate pioneer-factor binding and function [RNA-Seq]

先驱因子机制

转录因子染色质调控

While chromatin presents a barrier to the binding of many transcription factors, pioneer factors access nucleosomal targets and promote chromatin opening. Despite binding to target motifs in closed ch

NIAID Data Ecosystem20

mRNA-seq of PTC-028 treated fusion-positive rhabdomyosarcoma cells

融合阳性横纹肌肉瘤

BMI1抑制转录组分析

Purpose: This study aims to identify novel targets in the rare pediatric cancer, fusion-positive rhabdomyosarcoma (FP-RMS), and examine differences/similarities in FP-RMS tumor responses to BMI1 (B ly

NIAID Data Ecosystem30

OCT4-SOX2 dimers reshape the epigenome to promote neural crest multipotency [ATAC-Seq]. OCT4-SOX2 dimers reshape the epigenome to promote neural crest multipotency [ATAC-Seq]

神经嵴发育表观遗传

转录因子染色质调控

The transcription factors OCT4 and SOX2 play an essential role in the establishment and maintenance of pluripotent embryonic stem cells (ESCs). Yet, their function in specialized stem cell populations

NIAID Data Ecosystem20

Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma

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