CeO2@MSN@SB Nanoparticles Alleviate the Pathological Progression of Preeclampsia by Regulating Immune Balance and Gut Microbiota

Against this background, this study designed a novel cerium oxide-coated mesoporous silica nanoparticle loaded with sodium butyrate (CeO2@MSN@SB). The primary aim was to regulate gut microbiota and immune responses to improve pregnancy outcomes in a mouse model of PE. Specifically, the study investigated the effects of CeO2@MSN@SB on gut microbiota and its role in promoting macrophage M2 polarization, enhancing trophoblast function, and facilitating vascular remodeling