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The yeast CDP1 gene encodes a triple-helical DNA-binding protein
The formation of triple-helical DNA has been implicated in several cellular processes, including transcription, replication and recombination. While there is no direct evidence for triplexes in vivo,
PubMed Central2000-11-01 更新40
Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation
To understand genome-wide TopoI engagements in vivo, functional sites were mapped by employing a poisonous variant of the enzyme and a newly discovered inhibitor. Co-localization of binding and cleava
NIAID Data Ecosystem40
Table S1 - The Coordination of Centromere Replication, Spindle Formation, and Kinetochore�CMicrotubule Interaction in Budding Yeast
The relevant genotypes of the strains used in this study. (0.06 MB DOC)
Figshare2015-12-02 更新10
Ancestral sequence reconstruction reveals CTP-dependent parS binding as an ancient feature of ParB DNA segregation proteins
In most bacteria, chromosome and low-copy plasmid segregation are mediated by the ParABS system. Its component ParB functions as a DNA sliding clamp that assembles on centromere-like parS sites to for
NIAID Data Ecosystem40
Cells with reduced cohesion have impaired chromosome segregation.
(A) Separation velocity is reduced in cells overexpressing Topo IV. Cells bearing a tetO array at gln and expressing TetR-mCherry were transformed with pDB332, a weak Topo IV expression plasmid (Topo
NIAID Data Ecosystem20
