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Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH

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Protein Data Bank Japan2024-02-14 更新2026-03-21 收录
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Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH Descriptor: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cody, V. Deposit date: 2004-08-02 Release date: 2005-02-01 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61, 2005

解析Leu22突变体在甲氨蝶呤(Methotrexate)耐药性中的作用:野生型与Leu22Arg突变型小鼠及人二氢叶酸还原酶(dihydrofolate reductase)与甲氨蝶呤和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)的三元晶体复合物比较 描述项:二氢叶酸还原酶、甲氨蝶呤、烟酰胺腺嘌呤二核苷酸磷酸 作者:Cody, V. 存储日期:2004年8月2日 发布日期:2005年2月1日 最后修改日期:2024年2月14日 实验方法:X射线衍射(分辨率1.9埃) 引用文献:《解析Leu22突变体在甲氨蝶呤耐药性中的作用:比较野生型与Leu22Arg突变型小鼠及人二氢叶酸还原酶与甲氨蝶呤和NADPH的三元晶体复合物》,《晶体学报D辑》(Acta Crystallogr., Sect. D),第61卷,2005年
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2004-08-02
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