Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P218 and NADPH

Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with P218 and NADPH Descriptor: 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid, Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Yuthavong, Y, Vilaivan, T, Kamchonwongpaisan, S, Charman, S.A, McLennan, D.N, White, K.L, Vivas, L, Bongard, E, Chitnumsub, P, Tarnchompoo, B, Thongphanchang, C, Taweechai, S, Vanichtanakul, J, Arwon, U, Fantauzzi, P, Yuvaniyama, J, Charman, W.N, Matthews, D. Deposit date: 2012-02-13 Release date: 2012-11-14 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target Proc.Natl.Acad.Sci.USA, 109, 2012

携带四重突变（N51I+C59R+S108N+I164L）的恶性疟原虫（*Plasmodium falciparum*）二氢叶酸还原酶-胸苷酸合酶（dihydrofolate reductase-thymidylate synthase，缩写PfDHFR-TS）与P218及还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）形成的复合物
描述：3-(2-{3-[(2,4-二氨基-6-乙基嘧啶-5-基)氧基]丙氧基}苯基)丙酸、双功能二氢叶酸还原酶-胸苷酸合酶、还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）……
作者：Yuthavong, Y、Vilaivan, T、Kamchonwongpaisan, S、Charman, S.A、McLennan, D.N、White, K.L、Vivas, L、Bongard, E、Chitnumsub, P、Tarnchompoo, B、Thongphanchang, C、Taweechai, S、Vanichtanakul, J、Arwon, U、Fantauzzi, P、Yuvaniyama, J、Charman, W.N、Matthews, D.
保藏日期：2012-02-13
发布日期：2012-11-14
最后修改日期：2023-11-08
实验方法：X射线衍射法（分辨率2.4 Å）
引用文献：《疟原虫二氢叶酸还原酶：抗耐药性靶点药物研发的范式》，《美国国家科学院院刊》（Proc.Natl.Acad.Sci.USA），第109卷，2012年