BindingDB Entry 50002559: Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

Small molecule binding data for protein BRAF/CRAF, CDK-interacting protein 1, Cyclin-C, Cyclin-dependent kinase 19, Cyclin-dependent kinase 8, Cyclin-dependent kinase 8/Cyclin-C, Cyclin-dependent kinase 9, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Macrophage colony-stimulating factor 1 receptor, Mast/stem cell growth factor receptor Kit, RAF proto-oncogene serine/threonine-protein kinase, Rho-associated protein kinase 1, Rho-associated protein kinase 2, Tyrosine-protein kinase receptor FLT3, VEGF-receptor 2 and PDGF-receptor beta (KDR and PDGFR beta), Vascular endothelial growth factor receptor 1, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot A0A024R880, A0A024RCX5, A0A2P9DU05, L7RRS6, L7RSL3, O75116, P04049, P07333, P09619, P10721, P15056, P17948, P24863, P35916, P35918, P35968, P36888, P38936, P49336, P50750, Q13464, Q62447, Q7Z4L3, Q8R3L8, and Q9BWU1

本数据集包含针对以下蛋白靶点的小分子结合数据：BRAF/CRAF蛋白、CDK相互作用蛋白1、细胞周期蛋白C、细胞周期蛋白依赖性激酶19、细胞周期蛋白依赖性激酶8、细胞周期蛋白依赖性激酶8/细胞周期蛋白C、细胞周期蛋白依赖性激酶9、黏着斑激酶1/血管内皮生长因子受体3、巨噬细胞集落刺激因子1受体、肥大细胞/干细胞生长因子受体Kit、RAF原癌基因丝氨酸/苏氨酸蛋白激酶、Rho相关蛋白激酶1、Rho相关蛋白激酶2、酪氨酸蛋白激酶受体FLT3、血管内皮生长因子受体2与血小板衍生生长因子受体β（KDR与PDGFRβ）、血管内皮生长因子受体1、血管内皮生长因子受体2，以及血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR与TIE2）；同时涵盖以下统一蛋白质知识库（Universal Protein Resource，简称UniProt）编号：A0A024R880、A0A024RCX5、A0A2P9DU05、L7RRS6、L7RSL3、O75116、P04049、P07333、P09619、P10721、P15056、P17948、P24863、P35916、P35918、P35968、P36888、P38936、P49336、P50750、Q13464、Q62447、Q7Z4L3、Q8R3L8及Q9BWU1