RNA-sequencing in medial prefrontal cortex of early socially isolated mice

To explore the molecular mechanism underlying social isolation and resocialization, we performed RNA-seq on mPFC samples from the ~7-week-old control and social isolation mice. We identified 1265 differentially expressed genes (DEGs) that were enriched in 4 pathways: cognitive behavior, myelin development, synaptic development, and ion channels. Overall design: 7-week-old Control and Social isolation mice