A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent <i>in vivo</i> Antimalaria Activity
收藏NIAID Data Ecosystem2026-03-06 收录
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The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps and in good yields via oxoindole intermediates by employing tert-butyldimethylsilyl amine (TBDMSNH2) as previously unexplored ammonia equivalent.
创建时间：
2010-09-17
