Group statistics of the GWAS and the replication study cohorts.

The GWAS validation panel indicates numbers of patients (N) enrolled in the GWAS, after excluding microarrays that did not meet quality control criteria based on the PCA results. The ‘Range’ and ‘Median’ values regard age of cases and controls in respective groups. Both GWAS validation and replication analyses were done using respective individual patient TaqMan® genotyping. The TaqMan® genotyping data was subjected to a quality filtration using the 5% threshold of per-individual maximum genotype missingness (see ‘Statistical analyses – individual genotyping’).