Claim Verification: "Eating eggs significantly raises LDL cholesterol and heart-disease risk." — Disproved

Automated fact-verification of the claim: "Eating eggs significantly raises LDL cholesterol and heart-disease risk." Verdict: DISPROVED Key Findings SC2 (CVD risk) — directly contradicted: Two independent meta-analyses covering 1.7–2 million participants and 39–28 prospective cohort studies both find that moderate egg consumption (up to 1 egg/day) is not associated with increased cardiovascular disease risk (B1, B2 — both fully verified). SC1 (LDL) — threshold not met: The best RCT meta-analysis evidence (17 RCTs, healthy adults) shows an increase of 8.14 mg/dL in LDL-C with higher egg consumption (B3). This is statistically significant but falls below the 10 mg/dL threshold for clinical meaningfulness — and disappears in dietary contexts low in saturated fat. Compound claim fails: The claim requires BOTH sub-claims to hold. Neither does: SC1's "significantly" is not supported at the clinical level, and SC2 is directly contradicted by large-scale prospective evidence. Historical note: The 2015 U.S. Dietary Guidelines Advisory Committee removed the previous 300 mg/day dietary cholesterol limit, citing "no appreciable relationship between consumption of dietary cholesterol and serum cholesterol," signaling a major shift in the scientific consensus underlying this claim. Files proof.py — Re-runnable Python verification script proof.md — Structured proof report proof_audit.md — Full verification audit trail proof_narrative.md — Plain-language summary proof.json — Machine-readable structured data Generated by Proof Engine v1.0.0.针对声明"食用鸡蛋会显著升高低密度脂蛋白胆固醇（LDL-C）与心脏病风险"的自动化事实核查。 结论：已证伪。 核心研究发现 SC2（心血管疾病（CVD）风险）——直接相悖：两项覆盖170万至200万参与者、纳入39至28项前瞻性队列研究（prospective cohort studies）的独立荟萃分析（meta-analyses）均发现，适量食用鸡蛋（每日最多1个）与心血管疾病（CVD）风险升高无关联（B1、B2，两项均已完全验证）。 SC1（低密度脂蛋白（LDL））——未达到临床显著性阈值：针对健康成年人的最佳随机对照试验（RCT）荟萃分析证据（共17项RCT）显示，更高的鸡蛋摄入量会使低密度脂蛋白胆固醇（LDL-C）升高8.14 mg/dL。该结果具有统计学显著性，但未达到具备临床意义的10 mg/dL阈值，且在饱和脂肪摄入较低的饮食场景中该差异会消失。 复合声明不成立：该声明需要两个子声明同时成立，但两者均不满足：SC1中的"显著"未达到临床层面的支持标准，而SC2则被大规模前瞻性研究证据直接驳斥。 历史背景：2015年美国膳食指南咨询委员会移除了此前每日300mg的膳食胆固醇摄入上限，理由是"膳食胆固醇摄入与血清胆固醇水平之间无明显关联"，这标志着支撑该声明的科学共识发生了重大转变。 相关文件 proof.py —— 可重复运行的Python核查脚本 proof.md —— 结构化核查报告 proof_audit.md —— 完整核查溯源记录 proof_narrative.md —— 通俗语言总结 proof.json —— 机器可读的结构化数据 由Proof Engine v1.0.0生成。