S5 File -

(i). A listing of the MedR-CTG pairs of pivotal trials; and for these pairs, a comparison of the phase, and of the N1 and N2 values and attributes. a. A list of the ODs that did, or did not, list pivotal trials. b. The trials that were marked as pivotal, important, key or primary, that (i) did have CTG matches, (ii) that did have a CTG match, but for which N2 was unavailable and (iii) did not have CTG matches. c. A comparison of the N1 and N2 values for the 51 pivotal trials (a) The 51 pivotal trials with N1 and N2 values available; (b) N1; (c) N1+5%; (d) N1–5%; (e) N2; (f) trials where N1 = N2; and (g) trials where N2 was within +/- N1 and 5%. d. For 51 pivotal trials, (i) N1, (ii) N1 attribute, (iii) N2, (iv) N2 attribute and (v) whether or not the two attributes match. (ii). A comparison of the phase of each of 51 pivotal trials, as listed in the MedR and in CTG. e. An exact match, as deduced from the Clinical Trials Table. f. An exact match after a manual search of the entire MedR. g. An overlap, such as Phase 2b in CTG but Phase 2 in CTG or Phase 3 in CTG and Phase 2/3 in CTG. h. The word ‘phase’ was not linked to a given trial anywhere in the MedR.
(XLS)