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Effect of NMTi on senescence model systems

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE224071
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To examine effects of NMT inhibition on senescence transcriptional signatures we treated IMR90 ER:RAS cells with either IMP1088 (300nM) or DDD86481 (1.5uM) for 72h 7 days after induction with 4-OHT treatment. Transcriptional analysis was performed 3 days after drug treatment and 10 days after senescence induction. Comparative gene expression profiling analysis of RNA-seq data for IMR90 ER:RAS cells and its drug treatments.
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2024-01-02
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