Data set associated with a research on nephrotoxicity of gasoline fumes in male albino rat: A mechanism-based approach study

Few studies have reported nephrotoxicity of gasoline fumes in animals, but none of the findings has been fully ascertained and the mechanism underlying the observed toxicity still remains unknown. In this study, we present insights into the potential mechanism underlying the nephrotoxicity of gasoline fumes in 72 adult male albino rats. This study showed for the first time that accumulation of gasoline residues and metabolites in the kidney of exposed animal could potentially result in the generation of ROS capable of inducing renal dysfunction. The dataset uploaded are associated with this study.目前鲜有研究报道动物暴露于汽油烟气后的肾毒性，但所有相关研究结果均未得到完全证实，且该毒性的潜在作用机制仍未明确。本研究以72只成年雄性白化大鼠为对象，探讨汽油烟气致肾毒性的潜在作用机制。本研究首次发现，暴露大鼠肾脏内汽油残留物及其代谢产物的蓄积，可诱导活性氧（Reactive Oxygen Species）生成，进而引发肾功能异常。本次上传的数据集与本研究相关。