The COVID-19 patient-specific individual network.

The COVID-19 patient-specific network with relative contribution value (RC) represented by edge sizes. The network comprises 127 nodes and 412 edges (including 245 basal edges). The colored solid edges represent differentially regulated edges (DREs); SARS-CoV-2 (high MOI: 2) ∩ COVID-19-perturbed (magenta), SARS-CoV-2 (lowMOI: 0.2) ∩ COVID-19-perturbed (blue), SARS-CoV-2 (high MOI: 2) ∩ SARS-CoV-2 (low MOI: 0.2) ∩ COVID-19-perturbed (purple), COVID-19- perturbed exclusive edges (yellow). The dot edges represent the basal edges (grey). The nodes (green) represents the known drug target genes (See the paper: Supplementary Table S1). The node size stands for the extent of outdegree. In the Table, sample-labeled columns represent RC for each sample (COVID-19, healthy-1, healthy-2). The Bayesian network estimation was peformed using the publically available RNA-seq dataset (GSE147507). The detailed methods are described in the paper.