five

Thermotable core for biological chemistry

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DataCite Commons2025-10-31 更新2026-05-03 收录
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For more than a thousand chemical species of biological interest the table gives standard chemical, standard apparent chemical, and dtandard metabolic potentials: * Standard chemical potentials: extracted from various literature references (data sources indicated below the Table) * Standard apparent chemical potentials as the above standard chemical potentials but further transformed for H+ and ionic strength; for Alberty conditions (pH=7.14, pMg=3.57, I=0.25 M Osm=0 M) and for new biochemical conditions; for many more compounds than Alberty's 2006 Table. * Standard apparent chemical potentials for metabolic reference conditions (pH=7, pH=3, I=0.15 M Osm=.0.55 M) * Standard metabolic potential: as above but then further transformed with respect to CNOPS; tuned to mM concentration units and for .pH=7, pH=3, I=0.15 M Osm=.0.55 M. The standard chemical potentials are much more suitable for biology, biochemistry, metabolic engineering and enzymology than the standard chemical potentials were. They are good indicators of the biologically relevant Gibbs energy content of the molecules, as their concentration dependent terms are very small. The difference in standard metabolic potential between ATP and ADP is for instance very close to 50 kJ/mol, the actual Gibbs energy of ATP synthesis. Along metabolic pathways the standard mertabolic potentials tend to be smooth cascades whereas the standard chemical potentials shoot up and down. The standard metabolic potentials given are for pH=7, pMg=3, I=0.15 M, osmolarity = 0.55 M and a concentration of 1 mM (rather than the physical chemical reference state of pH=pMg=I=Omolarity=0; and 1 M activity), and temperatures of 25 C (e.g., this file) or 37 C (other files) and thereby very close to what is relevant in most biochemical conditions. No messing with activity coefficients is needed; concentrations (in mM) can be used in the expressions.
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2025-10-31
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