Single-unit auditory nerve fibre responses of young-adult and aging gerbils

This dataset was collected to study the functional consequences of age-related hearing loss for the auditory nerve, which carries acoustic information from the periphery to the central auditory system. Using high-impedance glass electrodes, raw voltage traces and spike times were recorded from more than one thousand single fibres of the auditory nerve of young-adult, middle-aged, and old Mongolian gerbils raised in a quiet environment. The dataset contains not only responses to simple acoustic stimuli to characterize the fibres, but also to more complex stimuli, such as speech logatomes in background noise and Schroeder-phase stimuli. A software toolbox is provided to search through the dataset, to plot various analysed outcomes, and to give insight into the analyses. This dataset may serve as a valuable resource to test further hypotheses about age-related hearing loss. Additionally, it can aid in optimizing available computational models of the auditory system, which can contribute to..., The dataset presented here contains the raw waveforms and spike times from single auditory nerve fibres of young-adult, middle-aged, and old gerbils, while presenting a variety of acoustic stimuli to assess the functioning of the single fibres. Gerbils were anesthetized with ketamine/xylazine injections and auditory brainstem responses (a type of compound response) were recorded to derive a measure of their general hearing sensitivity. The auditory nerve was approached dorsally through the cerebellum and a sharp, high-impedance glass electrode was slowly moved through the nerve. Single-unit recordings were made for as long as the surgical preparation was stable. Afterwards, spikes in the data were identified, data files were organized into folders of one single unit, data were analysed to characterize the fibre, and a set of criteria was used to ensure the single unit derived from the auditory nerve bundle. Methods are described in detail in the accompanying manuscript. , , # Single-unit auditory nerve fibre responses of young-adult and aging gerbils

[https://doi.org/10.5061/dryad.qv9s4mwn4](https://doi.org/10.5061/dryad.qv9s4mwn4)

This dataset contains the raw and processed data derived from single-unit auditory nerve fibre recordings in young-adult and aging gerbils. Using high-impedance, glass electrodes, raw voltage traces and spike times were recorded from over one-thousand single fibres of the auditory nerve of Mongolian gerbils raised in a quiet environment. Software was written and tested in MATLAB version R2023b.

## Description of the data and file structure

All raw, processed, and metadata of one animal is saved in one datafile ('G#.mat'). Such a .mat file contains one variable, 'exp', which is structured equally between all experiments. The content of each field in this struct is described in the document 'Data_Structure.pdf'. An overview of the metadata of each animal, e.g. age, hearing sensitivity, presented complex acoustic stimuli, numbe...,

本数据集的采集旨在研究年龄相关性听力损失对听神经（auditory nerve）的功能影响——听神经负责将声学信息从外周传递至中枢听觉系统（central auditory system）。研究采用高阻抗玻璃电极（high-impedance glass electrodes），对饲养于安静环境中的青年、中年及老年蒙古沙鼠（Mongolian gerbils）的听神经单纤维进行记录，累计获得超千条原始电压迹线与锋电位时间（spike times）数据。本数据集不仅包含用于表征纤维特性的简单声学刺激（acoustic stimuli）响应数据，还涵盖了背景噪声下的语音短词（speech logatomes）与施罗德相位刺激（Schroeder-phase stimuli）等复杂声学刺激的响应数据。配套提供了用于数据集检索、各类分析结果可视化以及解析分析过程的软件工具箱。本数据集可作为检验年龄相关性听力损失相关后续假说的宝贵资源，同时也有助于优化现有听觉系统计算模型，进而为……

本数据集包含青年、中年及老年沙鼠听神经单纤维的原始波形与锋电位时间数据，实验过程中通过呈现多种声学刺激以评估单纤维的功能状态。实验中，通过氯胺酮/甲苯噻嗪注射对沙鼠实施麻醉，并记录听性脑干反应（auditory brainstem responses，一种复合响应）以评估其整体听觉敏感性。采用经小脑背侧入路暴露听神经，随后将尖锐高阻抗玻璃电极缓慢插入神经组织，在手术状态稳定期间完成单单位记录（single-unit recordings）。后续对数据中的锋电位进行识别，将数据按单个单单位整理至对应文件夹，并对纤维特性开展分析，同时通过一系列标准验证所记录的单单位确来自听神经束。实验方法详见随附手稿。

# 青年与衰老沙鼠听神经单纤维响应
[https://doi.org/10.5061/dryad.qv9s4mwn4](https://doi.org/10.5061/dryad.qv9s4mwn4)

本数据集包含青年与衰老蒙古沙鼠听神经单单位记录的原始与处理后数据。实验采用高阻抗玻璃电极，对饲养于安静环境中的沙鼠听神经累计完成超千条单纤维的原始电压迹线与锋电位时间记录。配套软件基于MATLAB R2023b版本编写并测试。

## 数据与文件结构说明
单只实验动物的所有原始数据、处理后数据及元数据（metadata）均存储于单个数据文件（`G#.mat`）中。此类.mat文件包含一个名为`exp`的变量，所有实验的该变量结构保持一致。该结构体各字段的具体含义详见文档《Data_Structure.pdf》。每只实验动物的元数据概览包括年龄、听觉敏感性、所呈现的复杂声学刺激、数量……