Bespoke SnAP Reagents for the Synthesis of C‑Substituted Spirocyclic and Bicyclic Saturated N‑Heterocycles

The precise placement of C-substituents
on bicyclic and spirocyclic N-heterocycles is readily achieved by
the combination of aldehydes and new SnAP reagents. The substituted
SnAP reagents are readily prepared from simple starting materials
and couple with a variety of aromatic and heteroaromatic aldehydes
at room temperature under operationally simple conditions to deliver
substituted morpholine and piperazine products.