Brønsted Acid-Catalyzed Asymmetric Friedel–Crafts Alkylation of Indoles with Benzothiazole-Bearing Trifluoromethyl Ketone Hydrates
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https://figshare.com/articles/dataset/Br_nsted_Acid-Catalyzed_Asymmetric_Friedel_Crafts_Alkylation_of_Indoles_with_Benzothiazole-Bearing_Trifluoromethyl_Ketone_Hydrates/11968368
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An efficient Brønsted acid-catalyzed asymmetric Friedel–Crafts alkylation of indoles with benzothiazole-bearing trifluoromethyl ketone hydrates as electrophiles has been developed. The mild organocatalytic reactions proceeded well with low catalyst loading to afford a range of enantioenriched α-trifluoromethyl tertiary alcohols containing both benzothiazole and indole rings with excellent yields and enantioselectivities.
创建时间:
2020-03-02



