Whole genome sequence of Haemophilus influenzae serotype A in Japan.

Almost of invasive infection of Haemophilus influenzae in adult is caused by non-typeable Haemophisu influenzae so called NTHI. In the case of child, invasive infection of Haemophilus influenzae caused meningitides had been occurred by type b Haemophilus influenzae. However after introduction of Hib vaccine (The Haemophilus influenzae type B vaccine) for child as a regular vaccination in 2013, meningitides under 5 years old was decreased drastically. Serotype A Haemophilus influenzae is first report as an invasive infection by Haemophilus influenzae in both children and adults in Japan. There is no vaccine for adults to prevent invasive Haemophilus influenzae in Japan and around the world. For that purpose, it is necessary to accumulate biologically detailed data including the genome analysis of the causative bacteria causing invasive Haemophilus influenzae infection. The Haemophilus influenzae serotype A was isolated from 72-years old male accompany with pyogenic arthritis at Hyogo Prefectural Tamba Medical Center as a secondary emergency medical institutions. This bacterium was relatively susceptible to many antibiotics. In MLST analysis, it was ST1511, the same as Haemophilus influenzae serotype A isolated from the blood of a 65-year-old man in Australia in 2014.