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Base-Stabilized Nitrilium Ions as Convenient Imine Synthons

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Figshare2016-02-14 更新2026-04-29 收录
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A simple and efficient methodology is presented for the synthesis of a wide range of substituted imines. It is based on stabilizing readily available, but thermally labile, N-alkylnitrilium triflates with pyridine or DMAP to moderately air-stable adducts. These base-stabilized imine synthons react conveniently with phosphorus- and nitrogen-based nucleophiles to amidines and phosphaamidines.

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2016-02-14
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