Data - Werginz et al. - Differential intrinsic firing properties in sustained and transient mouse αRGCs match their light response characteristics and persist during retinal degeneration

Patch clamp data associated with Werginz et al. - Differential intrinsic firing properties in sustained and transient mouse αRGCs match their light response characteristics and persist during retinal degeneration

Data, as well as simplified load and plot functions. The data is the basis for figures 1, 2, 3 and 5 in Werginz et al. (10.1523/JNEUROSCI.1592-24.2024). Functionality includes loading results from a specified retinal ganglion cell (RGC) and plotting spiking output (e.g., membrane voltage over time) in response to visual stimulation as well as long (500 ms) and short (3 ms) current injections into the soma. Provided code does not perform threshold searching or other, more complex, analysis.

Context and methodology

Data was created by patch clamp electrophysiology of mouse alpha retinal ganglion cells (RGCs)

Light as well as intracellular stimulation was applied to test intinsic properties of different types of RGCs.

Technical details

Data can directly be loaded and plotted in Matlab running plotData.m (tested in Matlab R2024b)

Parameters to be specified:

cellID - identifier of each recorded cell, see list on top of plotData.m. Don't forget to add the folder prefix specifiying cell type (ONS, OFFS or OFFT)

The Data folder is structured into different cell types (ONS, OFFS or OFFT) data

The helperFunctions folder includes additional methods to extract and plot data

If help is needed feel free to reach out to Paul Werginz

Data is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0), the scripts are licensed under a MIT License.