It is becoming increasingly evident that the degradation of nuclear proteins requires nuclear-cytoplasmic trafficking of both the substrate proteins, as well as the E3 ubiquitin-ligases. Here, we show

PubMed Central40

Additional file 4 of HIF1α-dependent hypoxia response in myeloid cells requires IRE1α

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蛋白质互作组学

Additional file 4: Table S3. List of the proteins obtained after tandem mass spectrometry analysis of immunoprecipitation of HIF1α from J774 macrophages under hypoxia.

Figshare2023-06-21 更新30

Table_3_GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma.xlsx

肺腺癌分子机制

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G protein-coupled receptor kinase 6 (GRK6) is expressed in various tissues and is involved in the development of several diseases including lung cancer. We previously reported that GRK6 is down-regula

NIAID Data Ecosystem80

SET1B facilitates activation of the hypoxia response through site-specific histone methylation [ChIP-seq_2]

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组蛋白修饰

Hypoxia-inducible transcription factors (HIFs) are fundamental to the cellular adaptation to low oxygen levels but how they interact with chromatin and efficiently activate their target genes is uncle

NIAID Data Ecosystem40