Changes in liver, myocardium, and skeletal muscle transcriptome across early postnatal development in preterm newborns.

The dataset represents transcriptomes of liver (LI), myocardium (HM), and skeletal muscle (SM) from 41 mostly preterm human newborns who mainly died within several hours or days after birth. The Excel files contain raw read counts of all detected genes before filtering and filtered protein-coding genes data [raw, normalized, and regularized logarithm (log) transformed read counts excluding low-expressed genes]. Supported by the Ministry of Health of the Czech Republic, grant no. NU20-07-00026 and by the project National Institute for Research of Metabolic and Cardiovascular Diseases (Programme EXCELES, ID Project No. LX22NPO5104) funded by the European Union - Next Generation EU. The data provide a unique resource for the research of human perinatal development. The general description and analyses of all the data in all three tissues can be found in Janovska et al, 2025, Frontiers in Cell and Developmental Biology (doi: 10.3389/fcell.2025.1645959). A subset of the data has been used to characterize hepatic haematopoiesis in human newborns, as described in Janovska et al, 2025, Frontiers in Pediatrics (doi: 10.3389/fped.2025.1572836).本数据集涵盖41例绝大多数为早产的人类新生儿的肝脏（liver, LI）、心肌（myocardium, HM）以及骨骼肌（skeletal muscle, SM）转录组（transcriptome），这些新生儿多在出生后数小时至数日内死亡。Excel文件包含过滤前所有检测到的基因的原始读段计数（read counts），以及过滤后的蛋白编码基因（protein-coding gene）数据，其中包含排除低表达基因后的原始、标准化（normalized）及正则化对数（logarithm, log）转换后的读段计数。本研究受捷克共和国卫生部资助，项目编号NU20-07-00026；同时受欧盟下一代（Next Generation EU）资助的代谢与心血管疾病国家研究所项目（EXCELES计划，项目编号LX22NPO5104）支持。 本数据集为人类围产期发育（perinatal development）研究提供了独特的资源。三种组织全部数据的整体描述与分析结果可参见Janovska等人2025年发表于《细胞与发育生物学前沿（Frontiers in Cell and Developmental Biology）》的论文，DOI: 10.3389/fcell.2025.1645959。本数据集的一个子集已被用于表征人类新生儿肝脏造血（hepatic haematopoiesis）功能，相关研究详情参见Janovska等人2025年发表于《儿科学前沿（Frontiers in Pediatrics）》的论文，DOI: 10.3389/fped.2025.1572836。