Innate triggering and antiviral effector functions of activin A

Transcriptomic analyses delineated strikingly congruent patterns of gene regulation in hepatocytes stimulated with recombinant activin A and IFNα in vitro. Activin A mRNA, encoded by the INHBA gene, is induced upon activation of RIG-I, MDA5 and TLR7/8 viral nucleic acid sensors in vitro, across multiple cell lines and also in human peripheral blood mononuclear cells we first used microarray analysis and RNA sequencing to analyse the effects of activin A upon hepatocytes at the transcriptional level and examine its intersection with the type I IFN axis