Operons associated with a FNR ChIP-seq peak and lacking a FNR-dependent change in expression in GMM but are potentially co-activated by CRP and FNR (Category 3).

aGenomic location within each FNR ChIP-seq peak with the highest read count (the summit of the peak).
bFirst gene of the operon downstream of the FNR ChIP-seq peak, and operon designation was obtained from EcoCyc [70]. For peaks located within divergent promoters with both operons activated by CRP, both genes are identified, separated by “/”.
cIdentification number (B-number) for the first gene in each operon, obtained from EcoCyc [70]. For peaks located within divergent promoters with both operons activated by CRP, both B-numbers are identified, separated by “/”.
dFunctional description of the products of the operons, obtained from EcoCyc [70]. For peaks located within divergent promoters with both operons activated by CRP, the functions of both operons are listed, separated by “/”.
eIncrease of expression (+) or no change in expression (−) of gene as determined using microarray analyses when WT E. coli was grown with carbon sources other than glucose (e.g. glycerol, xylose, mannose, arabinose). For peaks located within divergent promoters the expression changes of both operons are listed, separated by “/”.
fIndication if the FNR site different than the CRP site (+) or overlapping the CRP site (−). For peaks located within divergent promoters the FNR and CRP site positions of both operons are listed, separated by “/”.
gReference for CRP activation of each operon or regulation in alternative carbon sources of each operon.