The effect of incorporating contact potentials on contact diversity.

Contact diversity was quantified by applying Eq (4) to the top N/2 contacts in each alignment and then averaging over every alignment in the dataset (first row: DCA on the Pfam dataset; second row: MetaPSICOV on the CASP12 dataset, see Methods), where N is the length of an alignment. The “alone” column contains the diversities when no contact potential is applied (that is, when DCA or MetaPSICOV scores alone are used to rank contacts). The remaining columns contain the diversities resulting from ranking contacts by hybrid scores that combine the corresponding co-evolution score and a contact potential (based on the four contact definitions in Table 1, respectively).