ONECUT2 gene body methylation

The transcription factor ONECUT2 (OC2) serves as a master transcriptional regulator in metastatic castration-resistant prostate cancer (CRPC) and represents a potential therapeutic target. Despite its significance, the mechanism regulating OC2 remains unclear. This study aims to analyze the possible role of gene body methylation of OC2 in its expression regulation and as a biomarker and/or therapeutic target for aggressive prostate cancer (PCa)