Mitochondrial Pathway Architecture: A Systems-Level Map of Target Connectivity for Precision Drug Design

Data deposit accompanying the manuscript: "A Computational Pathway Map of Mitochondrial Disease Targets: Network Topology and Therapeutic Implications." This dataset contains the target-pathway network data for 25 mitochondrial disease targets, including network edge lists (31 interaction edges), node attributes (gene symbols, UniProt IDs, MitoCarta3.0 pathway assignments, druggability classifications), and target-pathway associations. Targets were identified through computational analysis of mitochondrial disease pathways using ClinVar, UniProt, MitoCarta3.0, and PDB as primary data sources. Patent pending: US Provisional Application 64/018,624, filed March 27, 2026. This deposit contains research data only. The computational platform methods are protected by the referenced patent application. Manuscript series: DrugSynth AI / MitoCorex — Computational Drug Discovery for Mitochondrial Diseases (10 manuscripts).随附于学术论文的数据集：《线粒体疾病靶点的计算通路图谱：网络拓扑结构与治疗学意义》。 本数据集涵盖25个线粒体疾病靶点的靶点-通路网络数据，包含网络边列表（共31条相互作用边）、节点属性（基因符号、通用蛋白质数据库（UniProt）标识符、线粒体基因图谱数据库3.0（MitoCarta3.0）通路注释、成药性分类）以及靶点-通路关联关系。所有靶点均通过对线粒体疾病通路的计算分析筛选得到，主要数据源包括临床变异数据库（ClinVar）、通用蛋白质数据库（UniProt）、线粒体基因图谱数据库3.0（MitoCarta3.0）与蛋白质数据银行（PDB）。 该数据集相关专利处于待审状态：美国临时专利申请第64/018,624号，提交日期为2026年3月27日。本数据集仅包含研究数据，其涉及的计算平台方法受所引用的专利申请保护。 所属学术论文系列：DrugSynth AI / MitoCorex——《线粒体疾病计算药物发现》（共10篇论文）