Project Panacea: A Theoretical Convergent Science Framework for Salvus-Omni-1, a Broad-Spectrum Nanotherapeutic Concept for Viral Hemorrhagic Fevers

The manuscript, titled "Project Panacea: A Theoretical Convergent Science Framework for Salvus-Omni-1, a Broad-Spectrum Nanotherapeutic Concept for Viral Hemorrhagic Fevers," proposes a novel therapeutic approach to address Viral Hemorrhagic Fevers (VHFs) caused by RNA viruses from families such as Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae, which have mortality rates of 20–90%. Current treatments, limited by specificity, high costs, and viral resistance, are insufficient for diverse VHF strains. Salvus-Omni-1 integrates three components—HKI-789 (a TBK1 inhibitor to counter immune evasion), cs-siRNA-Vpol (an siRNA targeting conserved RdRp sequences), and IM-Calm22 (a peptide to mitigate cytokine storms)—encapsulated in targeted poly(lactic-co-glycolic acid) nanoparticles. Developed through a Convergent Science framework spanning over 50 disciplines, including AI-driven virology, synthetic biology, nanotechnology, and health economics, the concept is hypothesized to achieve 90–98% survival in non-human primate models across Ebola, Marburg, Lassa, and Crimean-Congo Hemorrhagic Fever, even at 72 hours post-exposure. This framework offers a scalable model for pandemic preparedness, aligning with WHO and CEPI guidelines for equitable global health security.《万灵药计划：针对广谱抗病毒出血热纳米治疗概念Salvus-Omni-1的理论汇聚科学框架》一文提出了一种新型治疗策略，用于应对由丝状病毒科（Filoviridae）、沙粒病毒科（Arenaviridae）、布尼亚病毒科（Bunyaviridae）及黄病毒科（Flaviviridae）等RNA病毒引发的病毒性出血热（Viral Hemorrhagic Fevers, VHFs），此类疾病的致死率达20%至90%。当前治疗手段受限于特异性不足、成本高昂且易诱导病毒耐药性，无法有效应对多样化的VHF毒株。Salvus-Omni-1整合了三种组分：HKI-789（一种可对抗免疫逃逸的TBK1抑制剂）、cs-siRNA-Vpol（一种靶向保守RNA依赖的RNA聚合酶（RNA-dependent RNA polymerase, RdRp）序列的小干扰RNA）以及IM-Calm22（一种可缓解细胞因子风暴的肽类药物），并将其包载于靶向聚乳酸-羟基乙酸共聚物（poly(lactic-co-glycolic acid, PLGA)）纳米颗粒中。该概念基于汇聚科学框架开发，涵盖包括AI驱动病毒学、合成生物学、纳米技术与卫生经济学在内的50余个学科领域，研究假设其可在埃博拉、马尔堡、拉沙热及克里米亚-刚果出血热的非人灵长类动物模型中实现90%至98%的存活率，甚至在暴露后72小时给药仍可达成该效果。该框架可为大流行防控提供可扩展的模型，符合世界卫生组织（World Health Organization, WHO）与流行病防范创新联盟（Coalition for Epidemic Preparedness Innovations, CEPI）提出的全球公平卫生安全指南。