Identification of evolutionary mechanisms of myelomatous effusion by single-cell RNA sequencing

Myelomatous effusion (ME) is a rare manifestion of extramedullary multiple myeloma (MM) with limited therapeutic options and poor outcomes. To investigate the evolutionary mechanisms of ME, we used single-cell RNA sequencing to assess the transcriptomes of bone marrow, peripheral blood, and pleural effusion/ascites from three patients with ME. We performed single-cell RNA sequencing of bone marrow, peripheral blood, and pleural effusion/ascites samples from three patients with ME to investigate the evolutionary mechanisms of ME. NOTE FROM SUBMITTER: We cannot submit the raw data files due to patient privacy concern.