scRNAseq of PC9 parental and persister cells

We performed scRNAseq of PC9 parental (PT) and persister cells (PS) at d1, d3 and d7 after being generated by treatment with BH3-mimetics. Trajectory analysis and differential expression along the pseudotime revealed the upregulation of the integrated stress response (ISR) and EMT signatures at early pseudotime, while gene expression profiles for cell cycle progression were upregulated at late pseudotime, characteristic for late PS and PT. Overall design: scRNAseq of PC9 parental and persister cells at d1, d3 and d7 generated by treatment with BH3-mimetics