Uric Acid-Knee OA

Osteoarthritis (OA), characterized pain and stiffness of joints has many risk factors. Of the many triggers, uric acid has been reported to initiate inflammation and drive the disease to severe forms. However, due to controversial reports, our study was designed to investigate the association of serum uric acid (sUA) levels in the different grades of Knee OA.
Methods: This cross-sectional study included 80 patients of knee OA, > 40 years of age, of both sexes who had not received any treatment other than analgesics. Subjects were stratified into 4 grades based on Kellgren and Lawrence radiological grading system. A detailed history of signs and symptoms, comorbidities, dietary and drug intake history were taken. The laboratory tests done were erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and sUA. Further reclassification of study population was done as early stage (grades 1& 2) and advanced stage (grades 3 & 4).