ICU-hospitalized severe patients (n = 40).

Values: N (%) unless stated otherwise.†Respiratory failure included moderate hypoxemia (in fourteen cases), acute lung injury with 200‡Thrombotic microangiopathy.¥Homozygous sickle cell anemia and vaso-occlusive crisis with acute chest syndrome (in one case), asthma (in one case), mitral stenosis and pulmonary edema (in one case).*Other included postpartum hemorrhage.○Pathological pulmonary imaging including interstitial syndrome (in nineteen cases), alveolar syndrome (in twenty-eight cases), and pleural effusion (in two cases).¶Secondary pulmonary infection included Streptococcus pneumoniae (in three cases) and Streptococcus sp., E. coli, Pseudomonas, Haemophilus, Klebsiella pneumoniae, Cytomegalovirus, and Aspergillus fumigatus infections (in one case each).◊Cardiac failure included cardiac dysfunction (in eight cases), vasoplegia (in eight cases), short cardiac arrest (in two cases), and pericarditis (in four cases).††Neurologic failure included ischemic cerebro-vascular disease (in one case), critical illness neuromyopathy (in two cases), hallucinations (in one case), and psychomotor agitation (in one case).**Other included immunoglobulins for the treatment of thrombotic microangiopathy.