Transcriptome analysis of genetically engineered murine fusion-negative rhabdomyosarcoma model-derived cell lines
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Fusion-negative rhabdomyosarcoma (FN-RMS) is the most common soft tissue sarcoma of childhood arising from undifferentiated skeletal muscle cells. Tumor cells derived from genetically engineered murine models are a valid tool to study cancer biology. In order to investigate the poor myogenic commitment of FN-RMS, we performed RNA sequencing of two cell lines derived from a previously described genetically engineered murine model of FN-RMS. We then performed bioinformatics analysis to compare the transcriptome with murine satellite cells, and identify the key factors that distinguish FN-RMS from skeletal muscle cells. Overall design: Bulk RNAseq of murine rhabdomyosarcoma cell lines This series includes re-analyzed satellite cell samples from GSE103164.
