Single cell RNA sequencing of embryonic thymuses from 22q11.2 DS mouse models following in utero drug treatments.

22q11.2 DS causes the formation of a hypoplastic thymus. Mouse models of 22q11.2 were used to study the impact of different drugs, administered in pregnant mice, on the growth of the thymus. Thymuses from the different treatments were processed for single cell RNA sequencing. These were from control (Tbx1+/+;+/neo2) and 22q mouse models (Tbx1neo2/neo2 ) Sc-RNA seq is performed on thymus cells isolated at E13.5 GA from a wild type embryo, Tbx1neo2/neo2 embryo, Tbx1neo2/neo2 embryo exposed in utero to Minoxidil drug and Tbx1neo2/neo2 embryo exposed in utero to PGE.2