Structure of Mycobacterium tuberculosis type II dehydroquinase complexed with (1R,4S,5R)-3-(benzo(b)thiophen-5-ylmethoxy)-2-(benzo(b) thiophen-5-ylmethyl)-1,4,5-trihydroxycyclohex-2-enecarboxylate

Structure of Mycobacterium tuberculosis type II dehydroquinase complexed with (1R,4S,5R)-3-(benzo(b)thiophen-5-ylmethoxy)-2-(benzo(b) thiophen-5-ylmethyl)-1,4,5-trihydroxycyclohex-2-enecarboxylate Descriptor: (1R,4S,5R)-3-(BENZO[b]THIOPHEN-5-YL)METHOXY-2-(BENZO[b]THIOPHEN-5-YL)METHYL-1,4,5-TRIHYDROXYCYCLOHEX-2-ENE-1-CARBOXYLATE, 3-DEHYDROQUINATE DEHYDRATASE, SULFATE ION Authors: Otero, J.M, Llamas-Saiz, A.L, Fox, G.C, Tizon, L, Prazeres, V.F.V, Lamb, H, Hawkins, A.R, Ainsa, J.A, Castedo, L, Gonzalez-Bello, C, van Raaij, M.J. Deposit date: 2011-01-28 Release date: 2011-08-17 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors. J. Med. Chem., 54, 2011

结核分枝杆菌（Mycobacterium tuberculosis）II型脱氢奎尼酸酶（type II dehydroquinase）与(1R,4S,5R)-3-(苯并[b]噻吩（benzo[b]thiophen）-5-基甲氧基)-2-(苯并[b]噻吩（benzo[b]thiophen）-5-基甲基)-1,4,5-三羟基环己-2-烯羧酸酯的复合物结构
描述物：(1R,4S,5R)-3-(苯并[b]噻吩（benzo[b]thiophen）-5-基)甲氧基-2-(苯并[b]噻吩（benzo[b]thiophen）-5-基)甲基-1,4,5-三羟基环己-2-烯-1-羧酸酯、3-脱氢奎尼酸脱水酶（3-dehydroquinate dehydratase）、硫酸根离子（sulfate ion）
作者：Otero, J.M、Llamas-Saiz, A.L、Fox, G.C、Tizon, L、Prazeres, V.F.V、Lamb, H、Hawkins, A.R、Ainsa, J.A、Castedo, L、Gonzalez-Bello, C、van Raaij, M.J
沉积日期：2011-01-28
发布日期：2011-08-17
最后修改日期：2023-12-20
实验方法：X射线衍射（2.5 Å）
引用文献：《提升强效结核分枝杆菌II型脱氢奎尼酸酶抑制剂抗结核活性的前药策略》，《药物化学杂志》，54卷，2011年