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RNA-seq to investigate sex-dependent changes in microglia in Cst7 knockout mice crossed with a mouse model of amyloid-driven Alzheimer's Disease

ChEBI2023-11-22 更新2026-07-12 收录

阿尔茨海默病转录组

小胶质细胞性别差异

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-13360 数据链接链接失效反馈

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资源简介：

RNA-seq to investigate sex-dependent changes in microglia in Cst7 knockout mice crossed with a mouse model of amyloid-driven Alzheimer's Disease

应用场景：

创建时间：

2023-11-22

阿尔茨海默病转录组

性别差异表达

Alzheimer’s disease (AD), the most common age-related neurodegenerative disease, is closely associated with and manifested by neuroinflammation, yet the alteration of immune landscape in AD is largely

NIAID Data Ecosystem120

Additional file 4 of C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer’s disease

阿尔茨海默病转录组

小胶质细胞极化

Additional file 4. Single-cell gene expression levels (counts).

Figshare2022-08-18 更新90

Cortical single-cell RNA sequencing of the microglia specific TREM2 inducible mouse models in the middle stage of amyloid deposition. Cortical single-cell RNA sequencing of the microglia specific TREM2 inducible mouse models in the middle stage of amyloid deposition

阿尔茨海默病转录组

小胶质细胞TREM2信号

We induced TREM2 expression at 2 months of age in our 5xFAD/TREM2 mouse models and harvested the animals at 5 months of age. The single cells from the cortex were isolated and subjected to the single-

NIAID Data Ecosystem70

Single-Cell RNA Sequencing of Brain Endothelial Cells in 12-Month-Old Male 5XFAD and Wild-Type Mice

阿尔茨海默病转录组

脑内皮细胞功能研究

This study investigates Alzheimer's Disease-related transcriptomic changes in brain endothelial cells of 5XFAD mice on the C57BL/6J background using single-cell RNA sequencing. Brains from male hemizy

NIAID Data Ecosystem110

Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer’s disease

阿尔茨海默病转录组

单核RNA测序

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that mostly strikes the elderly. However, the exact molecular and cellular pathogenesis of AD, especially the dynamic changes of ne

NIAID Data Ecosystem80

RNA-seq to investigate sex-dependent changes in microglia in Cst7 knockout mice crossed with a mouse model of amyloid-driven Alzheimer's Disease

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