Human PPAR Gamma Ligand Binding Domain in complex with a Gammma Selective Synthetic Partial Agonist MEKT76

Human PPAR Gamma Ligand Binding Domain in complex with a Gammma Selective Synthetic Partial Agonist MEKT76 Descriptor: N-(benzylsulfonyl)-4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)benzamide, Peroxisome proliferator-activated receptor gamma Authors: Oyama, T, Ohashi, M, Miyachi, H, Kusunoki, M. Deposit date: 2015-03-17 Release date: 2016-03-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Peroxisome proliferator-activated receptor gamma (PPAR gamma ) has multiple binding points that accommodate ligands in various conformations: Structurally similar PPAR gamma partial agonists bind to PPAR gamma LBD in different conformations Bioorg.Med.Chem.Lett., 25, 2015

人类过氧化物酶体增殖物激活受体γ（Peroxisome proliferator-activated receptor gamma, PPARγ）配体结合结构域与γ亚型选择性合成部分激动剂MEKT76的复合物。配体结构式为：N-(苄基磺酰基)-4-丙氧基-3-({[4-(嘧啶-2-基)苯甲酰基]氨基}甲基)苯甲酰胺，对应靶标为过氧化物酶体增殖物激活受体γ（PPARγ）。作者：Oyama T、Ohashi M、Miyachi H、Kusunoki M。提交日期：2015-03-17；发布日期：2016-03-02；最后修改日期：2023-11-08。实验方法：X射线衍射（分辨率2.2 Å）。引用文献：过氧化物酶体增殖物激活受体γ（PPARγ）拥有多个可容纳不同构象配体的结合位点：结构相似的PPARγ部分激动剂以不同构象结合PPARγ配体结合结构域（Ligand Binding Domain, LBD），刊载于《Bioorg.Med.Chem.Lett.》第25卷，2015年。