Crystal Structure of EGFR-T790M/V948R in Complex with TAK-788

Crystal Structure of EGFR-T790M/V948R in Complex with TAK-788 Descriptor: Epidermal growth factor receptor, SULFATE ION, propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate Authors: Niggenaber, J, Mueller, M.P, Rauh, D. Deposit date: 2020-08-25 Release date: 2022-02-23 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2 Å) Cite: Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J.Med.Chem., 65, 2022

EGFR-T790M/V948R与TAK-788复合物的晶体结构描述：组成涵盖表皮生长因子受体（Epidermal Growth Factor Receptor，EGFR）、硫酸根离子、异丙基 2-[[4-[2-(二甲氨基)乙基-甲氨基]-2-甲氧基-5-(丙酰氨基)苯基]氨基]-4-(1-甲基吲哚-3-基)嘧啶-5-羧酸酯。作者：Niggenaber J、Mueller M.P、Rauh D。存档日期：2020-08-25；发布日期：2022-02-23；最后修改日期：2024-11-13。实验方法：X射线衍射（分辨率2 Å）。引用文献：《采用野生型保留型抑制剂靶向表皮生长因子受体外显子20插入突变的研究》，《药物化学杂志》（J. Med. Chem.），2022年，第65卷。