Solid state NMR spectra of amyloid-beta fibrils derived from mouse brain tissue

One- and two-dimensional solid state NMR spectra of 40-residue amyloid-beta fibrils that were seeded with amyloid-enriched extracts from brain tissue of Tg2576 mice, which had been treated with two different synthetic fibril polymorphs (2F and 3F polymorphs) or with brain material from aged Tg2576 mice. The contents of each folder are described in the README.txt file. These solid state NMR data appear in a publication by R. Gomez-Gutierrez et al., entitled "Two Structurally Defined Abeta Polymorphs Promote Different Pathological Changes in Susceptible Mice".

本数据集包含40残基β淀粉样蛋白（amyloid-β, Aβ）原纤维的一维与二维固态核磁共振（solid-state NMR）谱。该类原纤维的接种诱导物为两类富集淀粉样蛋白提取物：其一取自经两种不同合成原纤维多态型（2F与3F多态型）处理的Tg2576小鼠脑组织，其二取自老龄Tg2576小鼠的脑组织。每个文件夹的内容均在README.txt文件中予以说明。本项固态核磁共振数据相关研究成果发表于R. Gomez-Gutierrez等人题为《两种结构明确的Aβ多态型可诱导易感小鼠产生不同病理变化》的学术论文中。