Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-331

Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-331 Descriptor: DIMETHYL SULFOXIDE, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1, ... Authors: Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. Deposit date: 2023-05-17 Release date: 2024-05-15 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.39 Å) Cite: Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024与SJPYT-331复合物结合的孕烷X受体（pregnane X receptor）配体结合域（ligand binding domain）晶体结构 描述：二甲基亚砜（DIMETHYL SULFOXIDE）、核受体亚家族1组I成员2（Nuclear receptor subfamily 1 group I member 2）、核受体辅激活因子1融合蛋白（Nuclear receptor coactivator 1 fusion protein）、核受体辅激活因子1（Nuclear receptor coactivator 1）…… 作者：Garcia-Maldonado E、Huber A.D、Nithianantham S、Miller D.J、Chen T 提交日期：2023-05-17 发布日期：2024-05-15 最后修改日期：2024-06-05 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.39埃） 引用文献：《核受体PXR的激活/抑制开关的化学操控》（Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR），《自然-通讯》（Nat Commun），第15卷，2024年