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In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions [Pofut1_microarray]

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NIAID Data Ecosystem2026-03-12 收录
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The role of nutrient signaling processes in the fate decision of CD8 is incompletely understood. By performing in vivo pooled CRISPR-Cas9 screening, we uncovered nutrient signaling processes underpinning the dynamics and heterogeneity of CD8 T cell fate decisions. We used microarrays to compare the global transcription profiles of WT or Pofut1-null P14 cells with or without NICD co-expression at day 7.5 post-infection from spleen.

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2021-03-01
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